Pathogenesis of Reactive Arthritis.

Pathogenesis of ankylosing spondylitis and reactive arthritis.

PURPOSE OF REVIEW The hallmark of ankylosing spondylitis is acute and chronic spinal inflammation initiating in the sacroiliac joints, often coupled with enthesitis, presenting as chronic inflammation at the sites of ligamentous and tendinous insertions into bone. Peripheral joint synovitis can be a prominent feature as well. Reactive arthritis is a sterile synovitis arising after an extra-arti...

Reactive Arthritis: From Clinical Features to Pathogenesis

Reactive arthritis (ReA) is a sterile synovitis which occurs after a gastrointestinal or urogenital infection. ReA belongs to Spondyloarthritis (SpA), a group of diseases that share several clinical and radiological features including familiar clustering, absence of rheumatoid factor and association with HLA-B27. Clinically, ReA is characterized by an asymmetric arthritis predominantly affectin...

The pathogenesis of HLA-B 27-related reactive arthritis.

Two major clues are provided to investigators regarding the pathogenesis of reactive arthritis. The first is that the arthritis is induced by infection with certain intracellular bacteria. These include Salmonella typhimurium, Shigella flexneri, Yersinia enterocolitica and Chlamydia trachomatis. The sec ond is that most patients are HLA-B 27 positive. Because the incidence of HLA-B 27 is very h...

Pathogenesis of Rheumatoid Arthritis

[Pathogenesis of rheumatoid arthritis].

Rheumatoid arthritis (RA) is an autoimmune systemic disease that primarily affects joints. Etiology and the pathogenesis of RA are complex, involving many types of cells, among others macrophages, T and B cells, fibro- blasts, chondrocytes and dendritic cells. Despite well documented role of many genes and epigenetic modifications in the development and evolution of the disease, in most RA pati...